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亚科因生物研发的重组人转铁蛋白（TF）（Human Transferrin protein）是一种基于人源序列表达的细胞因子蛋白，通过人类胚胎肾细胞表达系统制备，纯度高（≥95%），产品形式为冻干粉（冻干缓冲液为无菌PBS，pH 7.4），适用于细胞培养等生物医学研究应用。
转铁蛋白（TF）是一种铁转运蛋白，主要在肝脏合成，并在大脑中由少突胶质细胞和脉络丛等组织合成，参与脑脊液（CSF）的产生。脑脊液中存在两种亚型：脑型TF和血清型TF，其糖基化结构差异显著。脑型TF具有独特的双天线无唾液酸和无半乳糖复合N-聚糖结构，携带双分β1,4-GlcNAc和核心α1,6-Fuc，而血清型TF的糖基化与血清中相似。生化分析表明，脑型TF的表观分子量较小，并暴露疏水区域。研究表明，脑型TF水平在特发性正常压力脑积水中降低（CSF产生减少），而在自发性颅内低压中升高（CSF产生增加），提示其可作为CSF产生变化的潜在生物标志物。
应用领域：本产品专为细胞类研究设计，核心应用于细胞培养中作为生长因子支持细胞增殖与分化。同时，适用于神经科学领域（如脑脊液生物标志物研究）、铁代谢相关疾病模型构建，以及生物医学基础研究（如蛋白质相互作用分析）。
| 中文名称 | 重组人转铁蛋白(TF) |
| 英文名称 | Human Transferrin protein |
| 产品货号 | PRP2041 |
| 序列 | Amino acid sequence derived from Human Transferrin protein isoform (P02787, Met 1-Pro 698) with a polyhistidine tag at the C-terminus was expressed. |
| 标签 | 无标签 |
| 种属 | 人 |
| 活性 | 检测进行中 |
| 蛋白长度 | 重组人转铁蛋白由690个氨基酸组成，预测分子量为76.6 kDa。 在还原条件下，SDS-PAGE中人转铁蛋白的表观分子量约为70-100 kDa。 |
| 表达宿主 | 人类胚胎肾细胞 |
| 纯度 | ≥ 95 % ，使用SDS-PAGE检测 |
| 产品形式 | 冻干粉，冻干缓冲液为无菌的 PBS，pH 7.4。 |
| 分子量 | 76.6 kDa |
| 基因ID | 7018 |
| 蛋白质ID | P02787 |
| 蛋白序列链接 | https://www.uniprot.org/uniprot/P02787 |
| 分子 | TF |
| 注意事项 | 开盖使用前，请先离心。本产品为冻干粉，推荐用该产品配套的Reconstitution Buffer进行复溶，且浓度不低于100 µg/mL。客户可根据后续的实验需求，进行进一步的稀释。 |
| 保存建议 | 本产品为冻干粉形式，建议：将冻干粉的重组人转铁蛋白（TF）产品保存于-20℃以下的干燥环境中。本产品溶解之后，可在4℃保存2-7天，长期使用请置于-20℃以下。为长期保存，推荐添加载体蛋白（0.1% HSA或者BSA），并酌情分装保存，避免反复冻融。 |
| 运输条件 | 常温运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
Amino acid sequence derived from Human Transferrin protein isoform (P02787, Met 1-Pro 698) with a polyhistidine tag at the C-terminus was expressed.
The recombinant Human Transferrin protein consists of 690 amino acids and has a predicted molecular mass of 76.6 kDa. The apparent molecular mass of the Human Transferrin protein is approximately 70-100 kDa in SDS-PAGE under reducing conditions.
The recombinant Human Transferrin protein consists of 690 amino acids and has a predicted molecular mass of 76.6 kDa. The apparent molecular mass of the Human Transferrin protein is approximately 70-100 kDa in SDS-PAGE under reducing conditions.
Testing in progress.
Testing in progress.
< 1 EU per µg of the protein as determined by the LAL method.
< 1 EU per µg of the protein as determined by the LAL method.
Lyophilized from sterile PBS, pH 7.4.
Lyophilized from sterile PBS, pH 7.4.
Lyophilized Human Transferrin protein product should be stored desiccated below -18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Lyophilized Human Transferrin protein product should be stored desiccated below -18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human Transferrin protein using the buffer we provided not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human Transferrin protein using the buffer we provided not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.
Note: The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Note: The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Not for further distribution without written consent. Copyright © Abbkine, Inc.
Not for further distribution without written consent. Copyright © Abbkine, Inc.
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